· A retrospective study of 570 children diagnosed with multi-system inflammatory syndrome (MIS-C), nearly all of whom were confirmed COVID-19 positive by PCR or antibody test, found obesity to be the most common underlying condition, and 86% of cases involved 4+ organ systems, leading to 63.9% being admitted to the ICU with a median 5 day stay. The most common symptoms included abdominal pain and vomiting along with shock, myocarditis, and coronary artery dilatation, suggesting the importance of rapid recognition of the signs and symptoms of MIS-C.
· Neurologists in Spain present 2 cases of serotonin syndrome in COVID-19 positive males admitted with respiratory symptoms who were treated with lopinavir/ritonavir and hydroxychloroquine. They suggest that the combination of lopinavir/ritonavir with lithium and duloxetine in the first patient, and with risperidone and morphine in the second may have triggered the onset of serotonin syndrome, arguing that dose adjustment of antidepressants and antipsychotics should be considered in these patients.
R&D: Diagnosis and Treatment
· Analysis of the performance of three SARS-CoV-2 serological assays (from Abbott, Roche, and DiaSorin) using 1,154 serum samples from pre-COVID-19 patients and 65 serum samples from COVID-19 patients found the specificity of the assays were: 99.2% for Abbott), 99.7% for Roche, and 98.3% for DiaSorin. Assuming a 1% seroprevalence, the positive predictive value of the assays were: 52.3% for Abbott, 77.6% for Roche, 32.6% for DiaSorin.
· A systematic review consisting of 8 randomized control trials and observational studies investigated risks and benefits of short-term NSAID use in acute lower respiratory tract infections. The review discovered a trend toward reduction in mortality but increased pleuro-pulmonary complications though does note the studies exhibited high risks of bias due to lack of adjustment for confounding variables and should be interpreted as poor quality evidence. The authors emphasize the need for additional studies on NSAID use with respiratory infections to adequately assess the implications of use during the pandemic.
Mental Health & Resilience Needs
· A group of psychiatrists relay their correspondence with 14- to 25-year-olds in Europe and Africa to highlight the benefits of involving young people in the co-production of research and peer-led interventions during the current pandemic. They found that young people are highly motivated to support each other during this time by sharing experiences, exchanging fact-based information, and providing emotional support. By involving young people in these areas of civic engagement, the authors suggest a greater chance of building resilience in their communities, not only during the COVID-19 pandemic, but during future crises as well.