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January 28 | Daily COVID-19 LST Report

Understanding the Pathology

Virology experts from several Chinese institutions analyzed sera from 104 patients with severe COVID-19 admitted to Wuhan Jinyitan Hospital between January 17 and March 30, 2020. They found evidence that neutralizing antibodies (nAb) to SARS-CoV-2 persisted beyond 6 months while immunoglobulin (IgG) against receptor binding domains (RBD) and nucleocapsid protein (N) decreased from the acute infection phase to the convalescent phase. Authors suggest further studies with increased sample size and longer follow-up may help determine nAb’s role in long-term immunity and contribute to vaccine development.

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