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June 25 | Daily COVID-19 LST Report

Climate

· A survey of 2,402 adults in the United States found that 79.5% of respondents supported government-issued stay-at-home orders and nonessential business closures and 77.3% reported they were self-isolating at home suggesting that attitudes broadly support COVID-19 public health interventions.

· A review describes how the consideration of many sexual and reproductive healthcare facilities as non-essential during the COVID-19 pandemic has led to decreased accessibility to vital family planning services worldwide, highlighting the recent and expected increase in cases of unsafe abortions and gender-based violence, especially in developing countries.




Epidemiology

· A review of 82 studies found that the most consistent hemocytometric findings in patients admitted for COVID-19 were lymphopenia and an increased neutrophil-lymphocyte ratio – and these findings often intensify with more serious cases.

· A study of data on 1353 COVID-19 positive children found the three most common symptoms in these children were fever (21.7%), cough (15.4%), and abnormal breathing (8.1%) with the most severe manifestations, such as intubation or myocarditis, occurring in less than 0.7% of patients, and 1.9% of patients required ICU care.


Transmission and Prevention

· A report by the Center for Disease Control and Prevention of the COVID-19 outbreak that ocurred on the USS Theodore Roosevelt showed that 60% of respondents exhibited evidence of exposure to SARS-CoV-2 via positive neutralizing antibody assay, ageusia and anosmia were the symptoms most associated with current or previous infection among crew members, and 212 (90.2%) of the 235 respondents that reported a previous positive COVID-19 test via RT-PCR tested positive for neutralizing antibodies.


Management

· Guidelines for managing COVID-19 patients includes:

o Diagnosis, treatment, and prevention of venous thromboembolic disease

o Donor and candidate selection for transplants

· Pediatric specialists warn about the potential detrimental effects the COVID-19 pandemic will have on children, given the unprecedented shift to aggressive therapies such as early intubation which are yet to be specifically proven in pediatric patients.


Adjusting Practice During COVID-19

· A retrospective study found that patients with diminished ovarian reserve who delayed in vitro fertilization treatment (to 90 -180 days from their first visit) had similar live birth rates transfer than those that did not suggesting that delaying IVF in these patients does not affect live birth rate. This data can facilitate decision-making concerning treatment delays and disruptions in this population during the COVID-19 pandemic.


R&D: Diagnosis and Treatments

· A meta-analysis of 22 studies assessing the diagnostic efficiency of anti-SARS-CoV-2 IgG and IgM tests found specificities of 99% in both tests and sentisivities of 85% and 74% for IgG and IgM respectively.

· Analysis of SARS-CoV-2 IgM and total antibody levels in 192 patients with severe or mild COVID-19 found no statistically significant differences between mild and severe COVID-19 cases within 6 days of disease onset; however, after day 6, severe cases exhibited higher IgM and a higher overall positivity rate for total antibody titers than that of mild cases. Further, 12/35 mild cases never exhibited IgM positivity and 5/35 remained negative for total antibody titers highlighting the possible limitations in antibody testing of patients with mild COVID-19


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