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June 29 | Daily COVID-19 LST Report

Climate:

· A cross-sectional study of 640 adults found that COVID-19-related conspiracy theory (CT) beliefs correlated with pre-existing CT beliefs, lower education levels, and a negative perception of government responses. However, there was no correlation between CT beliefs and emotional stress during the pandemic.





Epidemiology:

· Overlap in symptomatology between e-cigarette associated lung injury (EVALI) and COVID-19 leads California health officials to urge providers to keep EVALI on the differential diagnosis

· A retrospective observational study of 91,412 women found that pregnant women with SARS-CoV-2 reported increased severe illness, chronic conditions, and risk of ICU admission than their non-pregnant counterparts. Pregnant hispanic and black women were also disproportionately affected, further highlighting the need to address social barriers.

· A multicenter retrospective cohort study from Wuhan comparing pediatric and adult COVID-19 patients found children were more likely to be asymptomatic, have lymphocytosis (vs lymphopenia in adults) and were less likely to respond to anti-viral treatments.

Understanding the Pathology:

· A prospective clinical study from the University of Utah suggest that SARS-CoV-2 infection induces activating changes in the transcriptome and proteome of platelets, possibly contributing to the immunothrombosis observed in COVID-19 disease.

· Mechanism-based research implicates genetic mutations on the SARS-CoV-2 spike (S) protein and furin cleavage site (FCS) on the evolution of disease, and differentiating between subtypes of COVID-19.


Transmission and Prevention:

· Japanese gastroenterologists present $1 disposable face shield made from cardboard, called “ORIGAMI”, for use in endoscopic procedures to mitigate SARS-CoV-2 transmission from droplet aerosolization.

· Canadian authors describe policies implemented to reduce spread of infection in a 182-bed psychiatric facility, concluding that rapid identification of cases, aggressive testing for carriers, and swift movement of patients to isolation units are necessary to reduce nosocomial spread of COVID-19.


Management:

· Spanish authors describe