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June 9 | Daily COVID-19 LST Report

Climate

· A case series conducted in Istanbul found that of over 50% of healthcare providers working in the COVID-19 care unit had developed hand eczema, suggesting that the increased hand hygiene techniques used to combat the transmission of COVID-19 may be leading to these effects.

· Public health experts in Quebec express optimism over the recent announcement by the Quebec government stating that COVID-19 healthcare will be covered for all residents regardless of immigration status. They hope that that this could set a precedent to help address the over 2/3 of migrants previously reporting unmet healthcare needs.

· Gerontologists argue that using age to create public policies for controlling the spread of COVID-19 is unjustified in that it reinforces negative age stereotypes and violates older persons’ rights to autonomy.


Epidemiology

· A review conducted by the Centers for Disease in June characterizes the initial spread of COVID-19 in the United States and concludes that community transmission of COVID-19 began in late January or early February 2020, with the primary strain originating in China and some additional strains likely coming from Europe.

· An epidemiological study of cases in Shenzhen, China utilized three parametric models to estimate the serial interval of COVID-19 as 5.9 days, which is shorter than that reported for SARS and MERS and supports a rapid transmission model that necessitates social isolation to control disease spread.

· A study of 71 hospitalized COVID-19 patients found that 9 exhibited hyperlipasemia; however, none of these patients developed acute pancreatitis or severe symptoms, suggesting that the presence of hyperlipasemia may not significantly affect clinical outcomes in patients with the virus.

· A case series in New York describes a group of 17 COVID-19 positive children and adolescents who presented with symptoms of a COVID-19-related inflammatory syndrome and suggest that the pattern of inflammatory markers follows closely with that of Kawasaki disease and that the pattern of abnormal cardiac findings necessitate long-term follow-up in these patients.

Understanding the Pathology

· An author at Montpellier University in France discusses the similarities between Kawasaki Disease (KD) and the "multisystem inflammatory" disease reported in COVID-19 cases and hypothesizes that dysregulation of neutrophil extracellular traps, which are DNA structures with antimicrobial proteins that trap and kill microorganisms, could be a link between the development of Kawasaki Disease and COVID-19.

· In vivo and ex vivo RNA sequencing of COVID-19 related genes in human tissue and immune cells found, among other findings:

o Higher expression of ACE-2 and CD-147 related genes in male, obese, COPD, hypertensive, asthmatic, and smoking patients

o Higher expression of CD-147 related genes with increased BMI and older age

o That children had lower expression of ACE-2 related genes, but hi