May 19 | Daily COVID-19 LST Report


Based on a 2018 systematic review of the SARS and MERS literature, authors identified key areas of research for these coronaviruses. They noticed that research was lacking in viral pathogenesis, clinical characterization, infection prevention and candidate therapeutics, and therefore recommend prioritizing research in these fields for the study of SARS-CoV-2.

May 19 | Daily COVID-19 LST Report


Contact tracing in Korea linked initial COVID-19 cases to several fitness class instructors. 26% of participants in their classes developed infection. Investigators speculate that the environment of a fitness class: a moist, warm atmosphere in a confined area coupled with turbulent airflow generated by intense physical exercise can lead to a higher rate of transmission.

IgG serology studies among staff members after a COVID-19 outbreak at a major German children’s and women’s hospital revealed the level of IgG did not correlate with symptom severity.

  • 22% of the patients with COVID-19 did not develop a measurable immune response within 20 days.

  • Some participants (without COVID-19) had an elevated response (IgG {1.8%}, IgA {7.6%}) irrespective of positive contact history.

An initially asymptomatic 23 year old female with COVID-19 confirmed by RT-PCR was found to have spontaneous pneumomediastinum on chest CT. The pneumomediastinum resorbed after seven days and the patient was discharged on day 10. The authors speculate that this presentation could be due to membrane damage caused by the virus, although the finding is difficult to explain in this patient who had minimal symptoms.

Researchers in Belgium reviewed literature and postings on social media from March 15 to May 10, 2020 to summarize neurological manifestations of COVID-19. Reported neurological manifestations include acute cerebrovascular diseases, CNS infection, seizures, anosmia or ageusia, and Guillain-Barré syndrome.

Understanding the Pathology