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May 26 | Daily COVID-19 LST Report

Climate

  • Investigators from the Harvard Business School, Indiana University School of Public Health, and the University of San Francisco’s Department of Medicine found that 41.2% of 3,512 hospitals and 302 hybrid health records were  unable to receive electronic COVID-19 surveillance data, demonstrating a crucial need for IT infrastructure in public health management of COVID-19.  



Epidemiology


Understanding the Pathology

  • case control study conducted at Northwestern University using 16 placental specimens from patients with severe COVID-19 found higher rates of maternal vascular malperfusion (MVM) and arterial arteriopathy, but no significant increase in acute or chronic inflammatory pathology when compared to controls, suggesting the importance of antenatal surveillance for these patients.  

  • A series of 10 autopsies on patients who died of COVID-19 in Sao Paulo, Brazil demonstrate damage to both epithelial and vascular tissues of multiple organ systems in COVID-19 including lungs, kidneys, spleen, lymph nodes, brain, testicles, and skin and fibrinous thrombi in the lungs of 80% of patients. 

  • An analysis of angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) transcriptome data from the Common Fund's Genotype-Tissue Expression (GTEx) Program found that ACE2/TMPRSS2 were expressed in salivary glands of healthy individuals with no significant variability between gender and age groups, suggesting a possible entry point for SARS-CoV-2