Investigators from the Harvard Business School, Indiana University School of Public Health, and the University of San Francisco’s Department of Medicine found that 41.2% of 3,512 hospitals and 302 hybrid health records were unable to receive electronic COVID-19 surveillance data, demonstrating a crucial need for IT infrastructure in public health management of COVID-19.
In a retrospective study of 72 COVID-19 patients admitted to the Beijing YouAn Hospital between January 21 and February 17, 2020 patients with severe and critical disease showed significantly lower lymphocyte counts and significantly higher leukocyte counts, neutrophil counts, and neutrophil-to-lymphocyte ratio at each time point when compared to patients with milder disease.
Swedish researches conducted a prospective cohort study finding a negative correlation between odor intensity and COVID-19 symptoms adding to recent reports that odor intensity may be a cost effective, easily implement method of estimating COVID-19 prevalence particularly in areas with limited access to testing. Radiologists from Marseilles, France briefly present the case of a SARS-CoV-2 positive 27-year-old who developed anosmia and dysgeusia with MRI showing bilateral olfactory bulb edema.
A mathematical iSAGE model estimated that the risk of COVID-19 can be reduced from 1.46% to 0.72% if the start dates for England schools is delayed from the first of June the first of September.
Understanding the Pathology
A case control study conducted at Northwestern University using 16 placental specimens from patients with severe COVID-19 found higher rates of maternal vascular malperfusion (MVM) and arterial arteriopathy, but no significant increase in acute or chronic inflammatory pathology when compared to controls, suggesting the importance of antenatal surveillance for these patients.
A series of 10 autopsies on patients who died of COVID-19 in Sao Paulo, Brazil demonstrate damage to both epithelial and vascular tissues of multiple organ systems in COVID-19 including lungs, kidneys, spleen, lymph nodes, brain, testicles, and skin and fibrinous thrombi in the lungs of 80% of patients.
An analysis of angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) transcriptome data from the Common Fund's Genotype-Tissue Expression (GTEx) Program found that ACE2/TMPRSS2 were expressed in salivary glands of healthy individuals with no significant variability between gender and age groups, suggesting a possible entry point for SARS-CoV-2