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May 27 | Daily COVID-19 LST Report

Climate

· Researchers call attention to ways the COVID-19 pandemic is unmasking healthcare disparities in two widely different groups, truck drivers and tuberculosis patients. In the words of London analysts who examined the impact on TB patients, care for these vulnerable populations should not be “sidelined”.

· On a similar theme, Australian researchers discuss the ethical dilemmas around distributive justice and fair resource allocation.




Epidemiology

· Adding to the literature on liver dysfunction and COVID-19, a meta-analysis of 20 retrospective cohort studies continues to support the use of liver function tests for monitoring disease progression.

· Literature reviews and case reports continue to clarify the diagnostic and prognostic value of dermatologic findings in COVID-19.

o Spanish researchers report the case of a 57-year old female who presented with erythema nodosum

o Egyptian physicians postulate herpes zoster reactivation may indicate latent COVID-19.

· Out of 3,406 COVID-19 patients, those younger than 50 with BMI above 40 kg/m^2 were associated with an 11.4% increase in mortality compared to those with lower BMI (p=0.019). Patients over 50 with elevated BMI were also associated with mortality, but to a lesser extent.

o Demonstrating that obesity over age being a stronger predictor of disease outcome

Understanding the Pathology

· A UK Biobank (UKB) to analysis of 322,948 subjects (mean age 68-years-old) found an association between the ApoE e4e4 allele and a positive COVID-19 test. Similar results were obtained after excluding patients with pre-existing conditions linked to COVID-19 severity, suggesting the ApoE e4e4 allele independently increases the risk of severe COVID-19 infection.


Transmission and Prevention

· An assessment of viral load in two COVID-19 patients in Seoul, Korea via nasopharyngeal and oropharyngeal swabs, s