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October 12 | Daily COVID-19 LST Report

Understanding the Pathology

· Findings from models of the change in energy (ΔΔG) of the binding of the SARS-CoV-2 spike (S) protein to the angiotensin converting enzyme-2 (ACE2) receptors from primates, rodents, birds, reptiles, and fish (n=215 vertebrates) suggest that a broad range of mammals are susceptible to SARS-CoV-2, indicating the need for surveillance of animals that are potential reservoirs.

Adjusting Practice During COVID-19

· A review of the major impacts of COVID-19 on specialty fields that treat non-communicable disease including cardiology (e.g alteration to STEMI), nephrology (e.g. dialysis centers complying with CDC recommendations and social distancing guidelines), obstetrics and gynecology (e.g. ACOG recommendations to separate neonates from COVID-19 positive mothers), hematology oncology (e.g. dramatic decreases in blood donations in some areas), as well as other specialties, found that the pandemic will likely result in negative impacts on many patients with non-communicable diseases, and may even lead to the development of de novo sequelae due to impaired healthcare practices.

Mental Health & Resilience Needs

· A opinion piece by a psychiatrist at Massachusetts General Hospital highlights that the rapidly changing nature of COVID-19 research and management has caused “Bayesian fatigue” by making the sum total knowledge a physician has gathered over their career less important than the most recent research, which has caused a negative psychological toll on physicians who long to see mastery and makes it difficult for physicians to counsel friends, family and patients as our knowledge on the COVID-19 pandemic is rapidly evolving.

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