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September 29 | Daily COVID-19 LST Report

Epidemiology

· Additional COVID-19 waves that could overwhelm hospital capacities by the end of 2020 if social distancing measures are relaxed without cocooning measures, say Data scientists from the University of Texas. Their mathematical model finds that relaxation of social distancing cannot occur without cocooning high risk populations such as long-term care residents and homeless persons, while providing continued incentive for the public to socially distance if we are to not overwhelm the healthcare systems’ ability to provide care.


Understanding the Pathology

· Serology tests that rely exclusively on N protein antibodies may not reliably indicate COVID-19 immunity. Investigators affiliated with University of Texas MD Anderson Cancer Center find that individuals who overcame COVID-19 were more likely to exhibit neutralizing antibodies against both S-RBD than N-protein, suggesting that serology tests relying exclusively on N-protein antibodies may not reliably indicate COVID-19 immunity.

Transmission & Prevention

· Greater caution is required and increased PPE use may be required for first responders and ED professionals A study by the Centers for Disease Control assessed correlations between the presence of SARS-CoV-2 antibodies and work exposure in 16,403 in high risk jobs. They found 6.9% of participants overall tested positive for SARS-CoV-2 immunoglobulin (IgG), with the highest seroprevalence in individuals exposed to an infected household member, living in multiunit housing or within 15 km of Detroit's geographical center and those employed as a nurse, nurse assistant, or in the emergency department.

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